Cytherea took her stage name from the Greek goddess of love, beauty, and music. She originally had a Yahoo! fan group when she was recruited by an agent into the adult industry. Her video career started in 2003, and she has performed in over 350 movies. Her first scene was with Tyce Bune for Ive Never Done That Before 14. Elegant Angel produced a series of movies featuring her dubbed as "Squirtwoman". Cytherea performed her first anal scene in the movie Cythereas Anal Whores in 2006.
She won the Best New Starlet Award from AVN in 2005. Also that year she made her feature dancing debut in Charlotte, N.C. at The Gentlemen’s Club. Cytherea formed a production company called Cytherea Productions in 2004.
In 2012, Cytherea signed with Ideal Image Management for representation, returning to performing after a brief stint in 2010–11 after a nearly four-year hiatus.
In 2014, Cytherea announced her intentions to crowdfund her return to the adult industry. She stated that since retiring from the industry in 2005, she has been a stay-at-home-mother to her two children. She also stated that she has had plastic surgery done in order to prepare herself for her return.
She has appeared on cable television shows, most notably the HBO/Cinemax series Sex Games: Vegas, Playboy TVs Night Calls and has been a guest on the Tom Leykis Showand The Howard Stern Show.
Cytherea also hosted an industry talk and interview radio show on KSEX in Los Angeles, California called Goddess of Gush. According to her website, the show was cancelled in 2006 and Cytherea has toured as a feature dancer in the past.
She has also had minor roles in a variety of movies such as the thriller Tumbling After and the comedy film Finishing the Game: The Search for a New Bruce Lee, both in 2007, and the cable television series Sex Games Vegas in 2005.